fMRI trial participants1
What this measured
Double-blinded, placebo-controlled trial with functional MRI performed before and one hour after low-dose administration.
Read Safety First
1 / 5Consumable · Mitochondrial Support
Omnivia Methylene Blue
Ten milligrams per serving. Two ingredients and water.
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$46.00
Methylene blue is unusual in this collection: a compound with a century and a half of clinical use behind it, which at low doses acts as an alternative electron carrier inside the mitochondrial electron transport chain.
In a double-blinded, placebo-controlled trial with functional MRI performed before and one hour after dosing, low-dose methylene blue increased brain activity during sustained attention and short-term memory tasks, and potentiated memory retrieval. Two ingredients and water.
It also has genuine contraindications. Read the safety section before you order.
In a double-blinded, placebo-controlled trial with functional MRI performed before and one hour after dosing, low-dose methylene blue increased brain activity during sustained attention and short-term memory tasks, and potentiated memory retrieval. Two ingredients and water.
It also has genuine contraindications. Read the safety section before you order.
30 days, opened or unopened — nothing to send back · Free shipping over $75 · Ships in 1–3 business days
fMRI trial participants
To measured effect
Pharmaceutical grade
- USP pharmaceutical grade — never industrial or aquarium grade
- Two ingredients and purified water
- Calibrated dropper for precise, repeatable dosing
- Backed by published human neuroimaging research
- Non-GMO, alcohol-free, fragrance-free
Shake well before each use. Take 1 ml — twenty drops — orally once daily, preferably in the morning. Fill the dropper and dispense directly into your mouth or add to your preferred beverage.
If well tolerated, a second serving may be taken later in the day. Do not exceed the recommended amount.
Blue-green urine for several hours afterwards is expected and harmless.
If well tolerated, a second serving may be taken later in the day. Do not exceed the recommended amount.
Blue-green urine for several hours afterwards is expected and harmless.
Methylene Blue Powder 10 mg, Water, Potassium Sorbate.
Non-GMO · Alcohol-free · Fragrance-free · Made in the USA.
Non-GMO · Alcohol-free · Fragrance-free · Made in the USA.
- GMO
- Alcohol
- Fragrance
- Additives
- Sweeteners
Every formulation carries a certificate of analysis, published in full on our certificates page. Coverage is matched to the product: microbiological profiles on nearly every formulation, heavy-metal limits for arsenic, cadmium, mercury and lead on ingestibles — with measured ICP-MS results where quantified — identity by FT-IR where run, physicochemical verification on every topical, and measured potency where an active assay is performed. Each certificate states its own specifications and results.
No formulation joins the collection without one. Read this product's certificate →
Complimentary shipping on orders over $75. Standard delivery 2–5 business days within the continental United States; express options at checkout.
Thirty-day money-back guarantee, opened or unopened. If a formulation is not working for you, contact concierge@omniviawellness.com — one opened container per formulation is refunded without sending anything back, and unopened products are refunded in full on return.
READ BEFORE USE. DO NOT TAKE if you are taking any serotonergic medication — including SSRIs, SNRIs, MAOIs, tricyclic antidepressants, triptans, tramadol, meperidine or St John's Wort. Methylene blue is a potent monoamine oxidase inhibitor and this combination can cause serotonin syndrome, a potentially life-threatening emergency.
DO NOT TAKE if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency — risk of haemolytic anaemia.
DO NOT TAKE if you are pregnant, may become pregnant, or are nursing.
Do not exceed the recommended serving. The dose-response relationship is hormetic; higher doses impair the mitochondrial function that low doses support.
The safety of this product has not been determined for children under eighteen or individuals with known medical conditions. Consult a healthcare professional before use. Keep out of reach of children. Do not use if the safety seal is broken or missing. Store in a cool, dry place.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
DO NOT TAKE if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency — risk of haemolytic anaemia.
DO NOT TAKE if you are pregnant, may become pregnant, or are nursing.
Do not exceed the recommended serving. The dose-response relationship is hormetic; higher doses impair the mitochondrial function that low doses support.
The safety of this product has not been determined for children under eighteen or individuals with known medical conditions. Consult a healthcare professional before use. Keep out of reach of children. Do not use if the safety seal is broken or missing. Store in a cool, dry place.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
The Evidence
What the research measured.
Methylene blue occupies an unusual position — a compound with real neuroimaging data and a long clinical history, sold across the wellness internet by people who mention neither its interactions nor its grade.
To measured effect1
What this measured
Interval at which increased brain activity during sustained attention and short-term memory tasks was recorded.
Pharmaceutical grade
What this measured
Industrial and aquarium-grade methylene blue carries heavy metal contaminants and must never be ingested at any dose.
Mechanism
How it works, at the level that matters.
At low concentrations methylene blue enters the mitochondrion — it is lipophilic and crosses membranes easily — and forms a renewable redox couple. It accepts electrons from NADH and donates them straight to cytochrome c oxidase, effectively bypassing complexes I and III of the electron transport chain.
The consequence is increased cytochrome oxidase activity, increased oxygen consumption and increased ATP production, particularly where the chain is partially impaired. Brain tissue, with the highest metabolic demand per gram in the body, is where this shows up most clearly on functional imaging.
The dose-response relationship is hormetic, and this matters enormously. At low concentrations methylene blue enhances electron transport. At high concentrations it does the opposite, acting as an electron sink and impairing the very process it otherwise supports. More is not better here. More is worse.
The consequence is increased cytochrome oxidase activity, increased oxygen consumption and increased ATP production, particularly where the chain is partially impaired. Brain tissue, with the highest metabolic demand per gram in the body, is where this shows up most clearly on functional imaging.
The dose-response relationship is hormetic, and this matters enormously. At low concentrations methylene blue enhances electron transport. At high concentrations it does the opposite, acting as an electron sink and impairing the very process it otherwise supports. More is not better here. More is worse.
Figures describe research on individual ingredients rather than on this finished product. Sources and the full disclosure are at the foot of the page.
The Formulation Story
Why we made
this one.
We debated whether to carry this at all.
Methylene blue has a serious mechanism, real human neuroimaging data, and a hundred and fifty years of clinical use. It also has an interaction profile that can put someone in hospital, and it is being sold across the wellness internet by people who mention neither the serotonin syndrome risk nor the difference between pharmaceutical and aquarium grade.
We decided a compound this misunderstood is better served by someone willing to sell it properly — USP grade, two ingredients, and the contraindications printed above the benefits.
If you take an SSRI, please close this page. We would genuinely rather not have your money.
Methylene blue has a serious mechanism, real human neuroimaging data, and a hundred and fifty years of clinical use. It also has an interaction profile that can put someone in hospital, and it is being sold across the wellness internet by people who mention neither the serotonin syndrome risk nor the difference between pharmaceutical and aquarium grade.
We decided a compound this misunderstood is better served by someone willing to sell it properly — USP grade, two ingredients, and the contraindications printed above the benefits.
If you take an SSRI, please close this page. We would genuinely rather not have your money.
Formulated for
Adults not taking any serotonergic medication, without G6PD deficiency, interested in mitochondrial support and cognitive performance. Frequently combined with Vitality NMN. Read the safety section in full before purchase.
The Formulation
Every active, named.
Every active, named. Consumable doses are printed to the milligram on the label. For topicals, actives are listed in order of concentration — and where a number cannot be independently verified, we do not print one.
Serving size
1 ml — twenty drops — once daily
2 fl oz / 60 ml
Methylene BlueMethylthioninium chloride
10 mg per 20-drop serving. At low concentrations it acts as an alternative electron carrier in the mitochondrial electron transport chain.
10 mg
Purified WaterUSP
The only other ingredient, alongside a trace of potassium sorbate for preservation.
The Protocol
How to use it, and what to expect.
Consistency is the variable that decides outcomes. Build the habit first; the biology follows on its own schedule.
1
Twenty drops, once daily
Shake well. Take 1 ml — twenty drops — orally in the morning, directly from the dropper or added to a beverage.
2
Morning only
Mildly stimulating in most people. Evening dosing tends to interfere with sleep onset, which is counterproductive if you are taking it for cognitive reasons.
3
Do not exceed the serving
The dose-response is hormetic. Above the low range methylene blue becomes an electron sink and impairs the mitochondrial function it otherwise supports.
1 hour
Acute window
The interval at which the imaging trial recorded increased activity during sustained attention and short-term memory tasks.
Day 1
Blue urine
Expected and harmless. Methylene blue is renally cleared and will tint urine blue-green for several hours. That is the compound leaving, not a side effect.
Week 1
Tolerance assessment
Stay at the recommended serving. If you experience any adverse effect, stop entirely rather than adjusting.
Ongoing
Intermittent use
Many users dose several days per week rather than daily. No trial has established an optimal long-term schedule and we will not invent one.
Questions
Before you begin.
Anyone taking a serotonergic medication — SSRIs, SNRIs, MAOIs, tricyclics, triptans, tramadol, or St John's Wort. Methylene blue is a potent monoamine oxidase inhibitor and the combination can precipitate serotonin syndrome, a medical emergency. Also contraindicated in G6PD deficiency, where it can cause haemolytic anaemia, and in pregnancy. If any of these apply, do not buy this product.
Because the compound is renally cleared and is, obviously, blue. Expect blue-green urine for several hours after dosing. It is harmless and it is the most reliable confirmation you have taken something active. It may faintly tint the tongue — rinse after dosing.
Because industrial and aquarium-grade methylene blue is the same molecule contaminated with heavy metals — arsenic, lead, cadmium — at levels acceptable for dyeing textiles and entirely unacceptable for human consumption. Never ingest methylene blue that is not USP grade.
Emphatically not. The dose-response is hormetic: low doses enhance electron transport, high doses reverse the effect and impair mitochondrial function. The published cognitive research used the low end of the range.
They are commonly combined and act on complementary parts of the same system — NMN replenishes the NAD⁺ substrate pool, methylene blue improves electron flux downstream of it. There is no known interaction between them. Every methylene blue contraindication still applies in full.
References
The research behind this formulation.
For anyone who wants to read further.
1.
Low-dose methylene blue increased fMRI activity during sustained attention and short-term memory tasks and potentiated memory retrieval in a double-blinded, placebo-controlled trial of 26 participants.Rodriguez P et al. Multimodal Randomized Functional MR Imaging of the Effects of Methylene Blue in the Human Brain. Radiology. 2016;281(2):516–526.
2.
Methylene blue at low concentrations forms a renewable redox complex within mitochondria, promoting cytochrome c oxidase activity, oxygen consumption and energy production.Rodriguez P et al. Radiology. 2016;281(2):516–526.
3.
Methylene blue preserved cytochrome oxidase activity and prevented neurodegeneration and memory impairment in a chronic cerebral hypoperfusion model.Methylene Blue Preserves Cytochrome Oxidase Activity and Prevents Neurodegeneration and Memory Impairment in Rats With Chronic Cerebral Hypoperfusion. Front Cell Neurosci. 2020.
Please note — These references describe studies of individual ingredients, not of this finished product. They are provided for educational purposes and do not constitute a claim that this product produces the same result. These statements have not been evaluated by the Food and Drug Administration.
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