Most Researched
Ingestible · Immune & Gut Integrity
Genesis Colostrum
2,300 mg of first-milking colostrum, standardised to 25% IgG.
$39.95
Colostrum is the first fluid a mammal produces after birth — dense with immunoglobulins and growth factors, and evolved for a single job: establishing a working immune system and an intact intestinal barrier in an organism that has neither.
The adult human evidence is unusually strong for a natural product. Pooled across randomised controlled trials, bovine colostrum reduced upper-respiratory symptom days by 44% and symptom episodes by 38% versus placebo. A separate meta-analysis found significant improvement in intestinal permeability. Each serving delivers 2,300 mg standardised to 25% IgG.
The adult human evidence is unusually strong for a natural product. Pooled across randomised controlled trials, bovine colostrum reduced upper-respiratory symptom days by 44% and symptom episodes by 38% versus placebo. A separate meta-analysis found significant improvement in intestinal permeability. Each serving delivers 2,300 mg standardised to 25% IgG.
Fewer symptom days
Fewer episodes
Standardised IgG
Third-party
tested Clinically
studied dose Made in
the USA
tested Clinically
studied dose Made in
the USA
- 2,300 mg of bovine colostrum, standardised to 25% IgG
- 575 mg of immunoglobulin G per serving
- Multiple independent human meta-analyses behind the ingredient
- Unflavoured — no sweeteners, gums or fillers
- Non-GMO, gluten-free, made in the USA
One scoop in 6–8 oz of cold water or a beverage of your choice, daily. Consume within ten minutes of mixing.
Never add to hot liquid — heat denatures the immunoglobulin fraction.
Never add to hot liquid — heat denatures the immunoglobulin fraction.
Bovine Colostrum (25% Immunoglobulin G) 2,300 mg, providing Immunoglobulins (IgG) 575 mg.
Vegetarian-suitable · Non-GMO · Gluten-free · Made in the USA. Contains milk.
Vegetarian-suitable · Non-GMO · Gluten-free · Made in the USA. Contains milk.
- Gluten
- GMO
- Added sugar
- Artificial sweeteners
- Fillers
Complimentary carbon-neutral shipping on orders over $150. Standard delivery 2–5 business days within the continental United States; expedited options at checkout.
Ninety-day returns, opened or unopened. If a formulation is not working for you, contact concierge@omnivia.com and we will refund you without requiring the product back.
CONTAINS MILK. Do not take if you have a dairy protein allergy.
For adults only. Do not exceed the recommended dose. Pregnant or nursing mothers, children under eighteen, and anyone with a known medical condition should consult a physician before use.
If you are immunosuppressed or taking immunomodulatory medication, speak with your physician first.
Keep out of reach of children. Do not use if the safety seal is damaged or missing. Store in a cool, dry place.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
For adults only. Do not exceed the recommended dose. Pregnant or nursing mothers, children under eighteen, and anyone with a known medical condition should consult a physician before use.
If you are immunosuppressed or taking immunomodulatory medication, speak with your physician first.
Keep out of reach of children. Do not use if the safety seal is damaged or missing. Store in a cool, dry place.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
The Evidence
What the research measured.
Bovine colostrum has something almost nothing else in this category can claim: multiple independent meta-analyses in humans, on endpoints that matter outside a laboratory.
Fewer symptom daysReduction in upper-respiratory symptom days versus placebo over eight to twelve weeks, pooled across randomised controlled trials.
Fewer episodesReduction in the incidence rate of upper-respiratory symptom episodes versus placebo in the same pooled analysis.
Standardised IgG2,300 mg of colostrum delivering 575 mg of immunoglobulin G per serving. The number is on the label because it is the whole point.
Mechanism
How it works, at the level that matters.
Two mechanisms, both at the intestinal barrier — which is where a surprising amount of immunity is actually decided.
The first is direct immunoglobulin delivery. Colostral IgG survives partially intact through the upper gastrointestinal tract and binds pathogens at the mucosal surface before they establish. This is passive immunity — borrowed antibodies rather than stimulated ones — which is why the effect appears within weeks rather than months.
The second is barrier restoration. Colostrum carries growth factors, principally IGF-1 and transforming growth factor beta, which promote enterocyte proliferation and tight-junction protein expression. In a randomised trial in athletes, participants who began with elevated intestinal permeability returned to the normal range after supplementation, with significantly reduced stool zonulin — a direct marker of tight-junction disassembly.
Standardisation is what connects this product to that research. Commercially available colostrum varies markedly in bioactivity; two powders can look identical and differ several-fold in immunoglobulin content. Ours is specified at 25% IgG, delivering 575 mg per serving.
The first is direct immunoglobulin delivery. Colostral IgG survives partially intact through the upper gastrointestinal tract and binds pathogens at the mucosal surface before they establish. This is passive immunity — borrowed antibodies rather than stimulated ones — which is why the effect appears within weeks rather than months.
The second is barrier restoration. Colostrum carries growth factors, principally IGF-1 and transforming growth factor beta, which promote enterocyte proliferation and tight-junction protein expression. In a randomised trial in athletes, participants who began with elevated intestinal permeability returned to the normal range after supplementation, with significantly reduced stool zonulin — a direct marker of tight-junction disassembly.
Standardisation is what connects this product to that research. Commercially available colostrum varies markedly in bioactivity; two powders can look identical and differ several-fold in immunoglobulin content. Ours is specified at 25% IgG, delivering 575 mg per serving.
Figures describe research on individual ingredients rather than on this finished product. Sources and the full disclosure are at the foot of the page.
The Formulation Story
Why we made
this one.
Colostrum became a trend, and the trend produced a great deal of very poor product — collected too late, dried at temperatures that wreck immunoglobulin structure, sold without a single number on the label.
The published literature is blunt about the consequence: bioactivity varies markedly between commercial colostrum products. Which means someone buying colostrum on the strength of the clinical evidence may be buying something with almost no relationship to what was studied.
So the number is the whole point. 2,300 mg standardised to 25% IgG, 575 mg of immunoglobulin per serving, printed where you can read it. That is the difference between a product that resembles the trial conditions and a powder that merely shares the name.
The published literature is blunt about the consequence: bioactivity varies markedly between commercial colostrum products. Which means someone buying colostrum on the strength of the clinical evidence may be buying something with almost no relationship to what was studied.
So the number is the whole point. 2,300 mg standardised to 25% IgG, 575 mg of immunoglobulin per serving, printed where you can read it. That is the difference between a product that resembles the trial conditions and a powder that merely shares the name.
Formulated for
Anyone with frequent upper-respiratory infections, heavy training loads, significant travel, or gut-barrier concerns. Widely used by endurance athletes, in whom most of the permeability research was conducted. Contains milk — not suitable for anyone with a dairy protein allergy.
The Formulation
Every active. Every milligram.
Every active, named. No amounts withheld. If it is in the bottle, the quantity is printed here — because a dose you cannot verify is a claim you cannot check.
Serving size
One scoop, daily
30 servings · 4 oz / 114 g
Bovine ColostrumStandardised to 25% IgG
2,300 mg per serving of first-milking bovine colostrum, standardised so you know what you are getting.
2,300 mg
Immunoglobulin GIgG fraction
575 mg per serving. The principal bioactive fraction, and the one the human research measures.
575 mg
Naturally occurring growth factorsIGF-1 · TGF-β
Present in colostrum as nature supplies it — the signalling proteins that make it what it is.
Proline-rich polypeptidesPRPs
Immunomodulatory peptides that appear to regulate rather than simply stimulate.
The Protocol
How to use it, and what to expect.
Consistency is the variable that decides outcomes. Build the habit first; the biology follows on its own schedule.
1
One scoop daily, in cold water
Mix into 6–8 oz of cold water or a beverage of your choice and drink within ten minutes. Never add to hot liquid — heat denatures the immunoglobulin fraction.
2
Empty stomach where you can
Twenty to thirty minutes before a meal reduces the proteolytic load on the immunoglobulins and improves the proportion reaching the intestinal surface intact.
3
Hold to eight weeks
The trials behind the 44% figure ran eight to twelve weeks. Barrier effects accumulate; they do not arrive in a fortnight.
Week 1–2
Adaptation
Some people notice mild digestive adjustment as gut flora responds. Halving the scoop for the first week resolves it in almost every case.
Week 4
Barrier markers move
The window in which trials measuring intestinal permeability and stool zonulin recorded significant change.
Week 8–12
Immune endpoints
The horizon on which pooled randomised trials recorded the 44% reduction in upper-respiratory symptom days.
Seasonally
Strategic use
Many people run colostrum continuously through winter and heavy travel or training periods, easing off when demand drops.
Questions
Before you begin.
No, and we would not sell it if it were. Colostrum is collected only after the calf has fed. A cow produces considerably more in the first days than one calf consumes, and the surplus was historically discarded.
Because published analysis found marked variability in bioactivity between commercial colostrum products. Two powders can be identical on the label and differ several-fold in immunoglobulin content depending on collection timing and processing temperature. Standardising to 25% IgG is what connects this product to the trials.
Colostrum contains considerably less lactose than mature milk and many people with mild intolerance take it without difficulty. It is not lactose-free, and it is emphatically not suitable if you have a dairy protein allergy. If your intolerance is significant, start at a quarter scoop.
Partially — that is the honest answer. A proportion of colostral IgG is degraded in the stomach; a meaningful proportion reaches the intestinal surface intact, and that surviving fraction is what the clinical outcomes reflect. Taking it on an empty stomach improves the ratio.
With protein powder, yes — many people do, and it is a common post-exercise combination. Not with coffee, or anything else hot. Heat denatures the immunoglobulins and you lose the reason you bought it.
References
The research behind this formulation.
For anyone who wants to read further.
1.
Bovine colostrum reduced the incidence rate of upper-respiratory symptom days by 44% and symptom episodes by 38% versus placebo over eight to twelve weeks.Jones AW, March DS, Curtis F, Bridle C. Bovine colostrum supplementation and upper respiratory symptoms during exercise training: a systematic review and meta-analysis of randomised controlled trials. BMC Sports Sci Med Rehabil. 2016;8:21.
2.
Risk of upper-respiratory tract infection was significantly reduced with bovine colostrum supplementation (RR 0.64; 95% CI 0.498–0.822) across seven trials and 445 randomised participants.Bovine colostrum supplementation in prevention of upper respiratory tract infections: systematic review, meta-analysis and meta-regression. J Funct Foods. 2022.
3.
Meta-analysis of randomised trials found a significant reduction in the five-hour urinary lactulose–rhamnose ratio, indicating improved intestinal permeability.Bovine Colostrum in Increased Intestinal Permeability in Healthy Athletes and Patients: A Meta-Analysis of Randomized Clinical Trials. Dig Dis Sci. 2023.
4.
Oral bovine colostrum decreased intestinal permeability and stool zonulin in athletes; 75% of the colostrum group began with elevated permeability and returned to the normal range.Hałasa M et al. Oral Supplementation with Bovine Colostrum Decreases Intestinal Permeability and Stool Concentrations of Zonulin in Athletes. Nutrients. 2017;9(4):370.
5.
Marked variability in bioactivity exists between commercially available bovine colostrum products, with direct implications for whether a given product can reproduce trial results.Marked variability in bioactivity between commercially available bovine colostrum for human use. PLoS One. 2020;15(6):e0234719.
Please note — These references describe studies of individual ingredients, not of this finished product. They are provided for educational purposes and do not constitute a claim that this product produces the same result. These statements have not been evaluated by the Food and Drug Administration.